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Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis

Identifieur interne : 001F06 ( Main/Exploration ); précédent : 001F05; suivant : 001F07

Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis

Auteurs : K. Nagashima [Allemagne] ; H. Wege [Allemagne] ; R. Meyermann [Allemagne] ; V. Ter Meulen [Allemagne]

Source :

Acta Neuropathologica [ 0001-6322 ] ; 1978-01-01.

RBID : ISTEX:369E68C698D702B8B55A1E25964175B363432E3E

Descripteurs français

KwdFr :
- Animaux, Axones (ultrastructure), Chiasma optique (ultrastructure), Encéphale (ultrastructure), Encéphalomyélite (anatomopathologie), Facteurs temps, Infections à Coronaviridae (anatomopathologie), Maladies démyélinisantes (anatomopathologie), Microscopie électronique, Moelle spinale (ultrastructure), Neurones (ultrastructure), Plasmocytes (ultrastructure), Pont (ultrastructure), Rats.
MESH :
- anatomopathologie : Encéphalomyélite, Infections à Coronaviridae, Maladies démyélinisantes.
- ultrastructure : Animaux, Axones, Chiasma optique, Encéphale, Facteurs temps, Microscopie électronique, Moelle spinale, Neurones, Plasmocytes, Pont, Rats.

English descriptors

KwdEn :
- Animals, Axons (ultrastructure), Brain (ultrastructure), Corona virus, Coronaviridae Infections (pathology), Demyelinating Diseases (pathology), Demyelination, Electron microscopy, Encephalomyelitis (pathology), Immunofluorescence, Microscopy, Electron, Neurons (ultrastructure), Oligodendrocyte and Astrocyte, Optic Chiasm (ultrastructure), Plasma Cells (ultrastructure), Pons (ultrastructure), Rats, Spinal Cord (ultrastructure), Time Factors, Weanling rats.
MESH :
- pathology : Coronaviridae Infections, Demyelinating Diseases, Encephalomyelitis.
- ultrastructure : Axons, Brain, Neurons, Optic Chiasm, Plasma Cells, Pons, Spinal Cord.
Teeft :
- Acta, Acta neuropathol, Animal model, Animals, Astrocyte, Axon, Brain suspension, Corona, Corona virus, Degenerating, Degenerating cells, Degeneration, Demyelinating, Demyelinating lesions, Demyelinating plaques, Demyelination, Different kinds, Early lesions, Electron microscopy, Encephalomyelitis, Endoplasmic reticulum, Glial, Glial cells, Gray matter, Higher magnification, Histological findings, Intracerebral inoculation, Lampert, Lesion, Macrophage, Microscopy, Electron, Microtubule, Mononuclear, Mononuclear cell infiltration, Mononuclear cells, Myelin, Myelin sheaths, Naked axons, Necrotic cells, Neuron, Neuropathol, Oligodendrocyte, Optic, Optic chiasma, Optic nerve, Other demyelinating diseases, Perivascular, Perivascular cuffing, Plaque, Plasma cells, Rats, Specific tracts, Spinal, Spinal cord, Subacute, Subacute demyelinating encephalomyelitis, Time Factors, Viral, Viral antigen, Virus infection, Virus particles, Weanling, Weanling rats, White matter.

Abstract

Summary: Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.

Url:

DOI: 10.1007/BF00691641

Affiliations:

Allemagne

Le document en format XML

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<term>Encéphalomyélite (anatomopathologie)</term>
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<term>Maladies démyélinisantes</term>
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<front><div type="abstract" xml:lang="en">Summary: Thirty percent of weanling rats infected with JHM murine corona virus developed a subacute demyelinating encephalomyelitis approximately 3 weeks after intracerebral inoculation. Small demyelinating foci were located in the deep cerebral white matter and large, sharply demarcated demyelinating lesions were detectable in optic chiasma, pons and spinal cord. Axons as well as neurons were well preserved in the demyelinating plaques in areas where the lesions extended to the gray matter. Perivascular cuffings, consisting of plasma cells and mononuclear cells, were frequently found. Viral antigen was found mostly in the white matter and in glial cells, leaving neurons unstained. Electron microscopic studies of the early lesions of white matter disclosed two different kinds of cell degeneration which developed prior to the myelin disruption and mononuclear cell infiltration. One was a small pyknotic cell, which is thought to be an oligodendrocyte and the other is a ballooned cell containing abundant microtubules. Virus particles could be demonstrated only in the latter cell type. Discussion about astrocytes as well as oligodendrocytes was made in relation to the initial stage of demyelination caused by virus infection. This animal model may be useful in the analysis of the mechanisms leading to demyelination in subacute or chronic infections.</div>
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Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis

Corona virus induced subacute demyelinating encephalomyelitis in rats: A morphological analysis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration Covid (26 mars)
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